René Brüggebusch Svensson Position:
Post doc
+45 3863 5870

Research focus:

In sports and exercise it is common to experience either an acute or an overload injury to the musculoskeletal system. Besides the muscles them selves, a common site of such injury are the connective tissues such as tendons and ligaments which connect muscles and bones. Connective tissues are made of strong nanoscopic threads called collagen fibrils. Collagen fibrils are responsible for the mechanical integrity of the human body and must maintain a proper balance of rigidity and flexibility. In spite of their important role the mechanical properties of these structures are largely unexplored because their nanoscale dimensions present a technical challenge. A number of clinical disorders as well as ageing are associated with altered mechanical properties of connective tissue, yet little is known about the mechanisms of these mechanical alterations. Using newly developed equipment we wish to bridge this gap, and our overall aim is to elucidate the nanoscale fibrillar basis for compromised connective tissue mechanical function caused by ageing as well as diseases like Ehlers-Danlos syndrome and hernia.

Specific projects:

  • Continuity of Collagen Fibrils Examined by 3D Electron Microscopy
  • Influence of Advanced Glycation on Collagen Fibril Mechanics
  • Changes to Collagen Fibril Mechanical Properties with Age
  • Composition, Structure and Mechanics of Collagen in Hernia Patients
  • Effect of Genetic Disease on Collagen Fibril Properties

Funded by:

Det Frie Forskningsråd – Sundhed og Sygdom: DFF – 1333-00052A
Brødrene Hartmanns Fond